골다공증이 유발된 척추운동분절에 생체 외 하중을 적용하였을 때 발생하는 기계생물학적 변화 관찰 : 예비연구
분야
의약학 > 의공학
저자
박지형 ( Ji Hyung Park ) , 이법이 ( Beob Yi Lee ) , 우대곤 ( Dae Gon Woo ) , 서동현 ( Dong Hyun Seo ) , 한태영 ( Tae Young Han ) , 김치훈 ( Chi Hoon Kim ) , 김한성 ( Han Sung Kim )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2012년, 제9권 239~245페이지(총7페이지)
파일형식
2a800498.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    To perform mechanobiological analysis about degenerative disc disease through osteoporotic functional segment unit (FSU) cultured in Biomechanical Lumbar Control System (BLCS), various types (compression or complex load) of physiologic mechanical forces were applied to in a controlled manner. The compression and shear load actuator were arranged vertically and horizontally, respectively, to control the complex load. The specimens (vertebral bodies) were scanned to investigate the morphological characteristics before culturing (0 week) and one week after culturing in BLCS by using high resolution in-vivo micro-computed tomography (micro-CT). Also, we implemented the histological method (H&E and Safranin-O staining) to observe the histomorphological changes of the intervertebral disc. The results for morphological characteristics showed that BV/TV, Tb.Th, Tb.Sp, Tb.N and SMI in compression loading group were almost not changed, compared with those of control group. However, BV/ TV, Tb.Th, Tb.N of complex loading group increased more than those of control group, and the contrary tendencies were represented in Tb.Sp and SMI. In the histological method, nucleus pulposus of compression loading group was so depressed that only central part was remained, therefore we could confirm that disc degeneration was considerably progressed. Also, complex loading group and control group had similar morphological changes in the nucleus pulposus parts. Trabecular bone volume didn`t increased and disc degeneration was accelerated in only compression loading condition group. It means that there was no more progress of disc degeneration. In this study, we tested compression and shear loading condition of everyday life applied to osteoporotic FSU by BLCS.
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