새로운 와이어 네트워크 몰딩 기법을 활용한 Scaffold 제작 및 특성평가
분야
의약학 > 의공학
저자
우창희 ( Chang Hee Woo ) , 김태영 ( Tae Young Kim ) , 이세환 ( Se Hwan Lee ) , 최기평 ( Ghi Pyoung Choi ) , 이승재 ( Seung Jae Lee ) , 김범수 ( Beom Su Kim ) , 유형근 ( Hyung Keun You ) , 조영삼 ( Young Sam Cho )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2012년, 제9권 308~315페이지(총8페이지)
파일형식
2a800507.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    In this study, we proposed a novel method which has several merits: guaranteed interconnectivity, solvent free, and unnecessary expensive devices. For the proposed novel method named as Wire-Network Molding, firstly, we prepare a mold with designed shape. Secondly, rectangular wires with thickness size 300 μm, 400 μm or 620 μm are inserted to make space for interconnected pore. After that, melted PCL (polycaprolactone) which is one of synthetic polymers with biocompatibility is filled in the mold and the mold is cooled at room temperature. Subsequently, wires are separated from the mold and the mold is removed from PCL. Consequently, the remained PCL has interconnected pores with a configuration of wire-network. To analyze the compressive modulus of the fabricated scaffold, UTM compression test is carried out. Moreover, we compare the compressive modulus of the fabricated scaffold with that of bio-plotter scaffold. Additionally, for scaffolds with 300 μm, 400 μm pore size, cell culture experiments are carried out using human.
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