Original Article : A Novel Method for the Production and Evaluation of Hernia Repair Mesh in an In Vitro Environment
의약학 > 의공학
( Bryant Mersereau ) , ( Richard E. Groff ) , ( Timothy Burg ) , ( Karen J. L. Burg )
조직공학과 재생의학 2012년, 제9권 제3호, 116~127페이지(총12페이지)
2a800484.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    156원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    While most hernia mesh researchers use animal models or patient studies to evaluate prostheses, we have developed an in vitro-centric mesh production and examination system to characterize mesh properties that affect the cellular affinity and treatment potential of repair mesh. A loom was designed and constructed, and a feasibility study was conducted on auto-loom woven, degummed silk mesh seeded with murine-derived D1 multipotent mesenchymal stromal cells (MSCs). Meshes of two different pore sizes, 1 mm and 2 mm, were investigated. The seeded meshes were evaluated using a variety of assays to determine cellular metabolic activity, viability, and conformation at time points of 7, 14, and 21 days. The assays showed substantial cell attachment to the mesh at all time points, including penetration of cells into the interior of silk threads. Metabolic activity peaked at Day 14 for both mesh sizes, with a sharp rise in protein production from Day 7 to 14. Based upon the successful production of mesh and acquisition of results from the assays performed, it can be concluded that an in vitro evaluation system for hernia mesh is both possible and likely to produce scientifically relevant results.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.