증례 : Gefitinib에 의해 유발된 반흔성 탈모증
분야
의약학 > 피부과학
저자
김민중 ( Min Joong Kim ) , 김정희 ( Jung Hee Kim ) , 이은주 ( Eun Ju Lee ) , 유박린 ( Bark Lynn Lew ) , 심우영 ( Woo Young Sim )
발행기관
대한피부과학회
간행물정보
대한피부과학회지 2013년, 제51권 제1호, 45~48페이지(총4페이지)
파일형식
27728588.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Epidermal growth factor receptor inhibitors (EGFRIs) are new anticancer agents that act by inhibiting EGFR signaling transduction pathways, thus decreasing tumor growth. They have made anti-cancer treatment more tolerable and have also reduced systemic side effects. However, they have many cutaneous side effects. Alopecia is an uncommon cutaneous side effect of EGFRIs, and cicatricial alopecia has been reported more rarely. A 59-year-old woman presented with itching and hair loss on the scalp, which started 2 months ago. She had been taking gefitinib for 7 months. A physical examination revealed localized erythematous hairless patches with scattered thick crusts on the scalp. Histopathologic examination showed a decreased number of hair follicles with perifollicular lymphocytes infiltration and perifollicular fibrosis, consistent with a scarring alopecia. We report a rare and interesting case of cicatricial alopecia after using the EGFRI, gefitinib. (Korean J Dermatol 2013;51(1):45∼48)
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