원저 : 융합성 망상 유두종증의 국소 Tretinoin 치료
분야
의약학 > 피부과학
저자
노태우 ( Tae Woo Noh ) , 강유석 ( Yoo Seok Kang ) , 이운하 ( Un Ha Lee ) , 박현수 ( Hyun Su Park )
발행기관
대한피부과학회
간행물정보
대한피부과학회지 2012년, 제50권 제11호, 937~944페이지(총8페이지)
파일형식
27728507.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Background: Confluent and reticulated papillomatosis (CRP) is a rare cutaneous disorder, characterized by persistent, scaling brown papules, patches, and plaques located on the trunk, neck, axillae, and shoulders. Many different treatments with variable success have been attempted, and oral minocycline treatment is effective in most patients with CRP. There were a few case reports of CRP responding to topical retinoid, but no clinical studies on the efficacy of the topical retinoid treatment for CRP have been reported. Objective: The purpose of this study was to evaluate the efficacy and safety of the topical tretinoin treatment for CRP. Methods: A retrospective study was performed based on the medical records and clinical photographs of patients with CRP treated with 0.025% tretinoin cream. Results: Nine patients (4 men and 5 women) were enrolled in the study. The mean age of the patients was 17.4 (11∼34) years and the mean age at onset of CRP was 15.1 (3∼33) years. The duration of disease varied from month to 7 years. Six of the nine patients showed complete remission, and CRP lesions improved markedly after averagely 6.2 weeks from the beginning of the topical tretinoin treatment. The treatment response was better in patients without itch than in patients with itch (p=0.048). Adverse effects were detected in 3 patients, and were mild irritant contact dermatitis to the topical tretinoin. Conclusion: We think that topical 0.025% tretinoin treatment is an effective and safe treatment modality for CRP and this treatment can be an alternative or additional modality to the systemic treatment. (Korean J Dermatol 2012; 50(11):937∼944)
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