ORiginal Article : Clinical Outcomes and Predictive Factors for Response after the First Course of Corticosteroid Therapy in Patients with Crohn`s Disease

분야: 의약학 > 내과학
저자: ( Duk Hwan Kim ) , ( Jae Hee Cheon ) , ( Jae Jun Park ) , ( Jin Young Yoon ) , ( Chang Mo Moon ) , ( Sung Pil Hong ) , ( Tae Il Kim ) , ( Won Ho Kim )
발행기관: 대한소화기학회
간행물정보: Gut and Liver 2013년, 제7권 제1호, 58~65페이지(총8페이지)
파일형식: 07811363.pdf [무료 PDF 뷰어 다운로드]
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ORIGINAL ARTICLE : Clinical Outcomes and Predictive Factors for Response after the First Course of Corticosteroid Therapy in Patients with Crohn`s Disease

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영문초록

Background/Aims: This study sought to determine the natural course of Crohn`s disease (CD) and identify predictors that could indicate responsiveness to corticosteroid (CS) therapy. Methods: Patients with active CD who were treated with oral CS at a single institution between August 1994 and February 2008 were retrospectively reviewed. The clinical outcomes at 1 month, 4 months, and 1 year after the treatment, as well as clinical and biochemical parameters at the time of CS initiation, were evaluated. Results: A total of 96 patients with CD were enrolled. In this study, 37 patients achieved complete remission (38.5%), 49 achieved partial remission (51.0%), and 10 (10.4%) showed no response at 1 month after the initiation of CS treatment. At 4 months and 1 year after treatment, 66 (69.5%) and 47 (56.6%) patients showed prolonged response, 22 (23.2%) and 20 (24.1%) showed steroid dependency, and 7 (7.4%) and 16 (19.3%) showed refractoriness, respectively. Nonstricturing and nonpenetrating behaviors and a lower CD activity index demonstrated clinical significance for mid-term or mid- and long-term steroid responses, respectively. Conclusions: The short-term response rate to initial oral CS therapy in CD was considerably high, but responsiveness thereafter showed a tendency to decrease with time. Clinical parameters reflecting mild inflammation were associated with responsiveness after CS treatment. (Gut Liver 2013;7:58-65)

#Inflammatory bowel diseases # Crohn disease # Adrenal cortex hormones # Steroids

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