Review : Recent Advances in the Pathophysiology and Treatment of Gastroparesis
분야
의약학 > 내과학
저자
( Jung Hwan Oh ) , ( Pankaj J Pasricha )
발행기관
대한소화기기능성질환·운동학회(구 대한소화관운동학회)
간행물정보
Journal of Neurogastroenterology and Motility 2013년, 제19권 제1호, 18~24페이지(총7페이지)
파일형식
19201862.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Gastroparesis is a clinical disorder characterized by upper gastrointestinal symptoms related with delayed gastric emptying of solids and liquids in the absence of mechanical obstruction. Diabetes mellitus has been the most common cause of gastroparesis and idiopathic gastroparesis also accounts for a third of all chronic cases. The most important mechanisms of gastroparesis, as understood to date, are loss of expression of neuronal nitric oxide synthase and loss of the interstitial cells of Cajal. However, the pathogenesis of gastroparesis is poorly understood. There have been several studies on specific molecules related to the pathogenesis of gastroparesis. Additionally, the Gastroparesis Clinical Research Consortium of the National Institutes of Health has achieved several promising results regarding the pathophysiology of gastroparesis. As the progress in the pathophysiology of gastroparesis has been made, a promising new drug therapy has been found. The pathophysiology and drug therapy of gastroparesis are focused in this review. Until now, the real-world medication options for treatment of gastroparesis are limited. However, it is expected to be substantially improved as the pathophysiology of gastroparesis is elucidated. (J Neurogastroenterol Motil 2013; 19:18-24).
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