The aim of this study was to evaluate the physiological and psychological effects of foot and hand massage in female university students. The pre-test/post-test design was planned as a randomized controlled experimental study. The total 102 subjects were selected by random sampling method and participants` presenting orders and then evenly divided into three groups; a control group (n=34), a foot and hand massage group (n=35), and a foot massage group (n=33). For the physiological effects, blood pressure, pulse and respiration were measured. For the psychological effects, pain intensity expressed as a numerical rating scale was measured. The measurement of three times, including immediately before, right after, and 90 min after massage was conducted. Both in physiological and psychological measurement, all the values measured at after massage significantly (p?0.05 or p?0.001) decreased in the both intervention groups only except the pulse (p¤0.05) in the foot massage group. These results show that foot and hand massage is more effective than foot massage. Therefore, foot and hand massage could be a useful tool as an effective therapy intervention.