활성산소 소거활성에 따른 꾸지뽕잎 추출물의 신경세포 보호 효과
분야
농학 > 식물
저자
강용경 ( Young Kyoung Kang ) , 이은아 ( Eun Ah Lee ) , 박해룡 ( Hae Ryong Park )
발행기관
한국식품조리과학회(구 한국조리과학회)
간행물정보
한국식품조리과학회지 2012년, 제28권 제6호, 821~828페이지(총8페이지)
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25332634.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    In an attempt to identify the neuroprotective effect of Cudrania tricuspidata (CT) leaves against ROS (reactive oxygen species)-induced oxidative stress in neuronal cells, the extracts from CT leaves were investigated using PC12 cells and N18-RE-105 cells. The methanolic and ethanolic extracts from CT were denoted as CTM (Cudrania tricuspidata Leaves methanolic extracts) and CTE (Cudrania tricuspidata Leaves ethanolic extracts), respectively. The neuroprotective effects of the extracts were measured by DEF-DA assay, MTT reduction assay, and LDH release assay. The PC12 cells exposed to H2O2-induced oxidative stress and the N18-RE-105 cells exposed to glutamate-induced oxidative stress were treated with various concentrations of CTM and CTE. The results, CTM treatments resulted in the induction of a dose - dependent protective effect in PC12 cells and N18_RE-105 cells. Interestingly, CTE also showed neuroprotective effect in PC12 cells and N18-RE-105 cells. Therefore, these results suggest that CTM and CTE could be a new porential candidate as neuroprotective agents against ROS-induced oxidative stress in neuronal cells.
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