원저 : 직장 카르시노이드 종양에서 Ki-67 발현의 예후적 중요성
분야
의약학 > 내과학
저자
홍수민 ( Su Min Hong ) , 김유선 ( You Sun Kim ) , 문정섭 ( Jung Seop Moon ) , 김진남 ( Jin Nam Kim ) , 오명기 ( Myoung Ki Oh ) , 권선옥 ( Sun Ok Kwon ) , 정성연 ( Seong Yeon Jeong ) , 홍성우 ( Seong Woo Hong ) , 강윤경 ( Yun Kyung Kang )
발행기관
대한소화기학회
간행물정보
대한소화기학회지 2013년, 제61권 제2호, 82~87페이지(총6페이지)
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07811383.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Background/Aims: Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors. Methods: We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis. Results: The mean age (±SD) of the patients was 56.3±10.7 years, and the male : female ratio was 3.6:1. The mean tumor size was 0.5±0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7±1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4±25.4 months, and no recurrences were observed. Conclusions: In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.
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