On the base of EU foreign policy, this paper examines the relationship between France and Italy and the Maghreb regions. Indeed, France and Italy among the European counties surrounding the Mediterranean have politically and economically influenced to and also have been affected by North African countries which were once their colonies. This article deals with the diversified cooperative relations between France and Italy and the North African countries belong to Arab Maghreb Union(AMU). Italy is actively engaged in helping to foster stability in the Maghreb area and relations with the European Union. And it has contributed to reviving the 5+5 Dialogue, with the active participation of Libya. It supports initiatives aimed at breathing new life into the AMU. France`s policy toward the Maghreb countries is in accordance with her traditional interests in the region. However after the modestly successful Barcelona conference in 2005, the Euro-Mediterranean Partnership has not succeeded in rejuvenating its commendable initiative. Apart from examining the concerns regarding the Maghreb regions that have become crucially important for interests (security, immigration, development, energy) of France and Italy, the article analyses the salient elements of bilateral relations between them.