Intraoral precancerous lesions can be diagnosed early through noninvasive and fast diagnosis using an autofluorescent device. The purpose of this study was to evaluate the usefulness of Visually Enhanced Lesion Scope (VELscope; LED Dental Inc.) as a diagnostic device for oral cancer. Materials and Methods: In this study, 24 6-week-old mice were divided into two groups: six mice in the control group and 18 in the experimental group. Conditions of mices` tongues were evaluated after developing epithelial dysplasia using 4-nitroquinoline-l-oxide (4NQO, Sigma Aldrich) solution. Clinical photos were taken with Velscope, which diagnoses oral cancer using an autofluorescent device. Histological analysis was conducted every 4, 8, and 12 weeks for comparison with Velscope images. Results: Oral epithelial dysplasia was observed on tongues treated with 4NQO solution for 8 weeks. As time went by, dysplasia progressed and carcinogenesis was observed. The developing grade of dysplasia was moderate grade. Conclusion: Therefore, after dysplasia develops, lesion cloud could be distinguished by visual inspection and Velscope, although it remains to be confirmed whether Velscope is more beneficial than clinical visualization.