원저 : 상피이형성 발생 마우스 모델에서의 VELscope를 이용한 진단의 유용성 평가
분야
의약학 > 기초치의학
저자
김문섭 ( Moon Seob Kim ) , 문성용 ( Seong Yong Moon ) , 김수관 ( Su Gwan Kim )
발행기관
조선대학교 치의학연구원(구 조선대학교 구강생물학연구소)
간행물정보
Oral Biology Research (OBR) 2013년, 제37권 제1호, 20~24페이지(총5페이지)
파일형식
71201263.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Intraoral precancerous lesions can be diagnosed early through noninvasive and fast diagnosis using an autofluorescent device. The purpose of this study was to evaluate the usefulness of Visually Enhanced Lesion Scope (VELscope; LED Dental Inc.) as a diagnostic device for oral cancer. Materials and Methods: In this study, 24 6-week-old mice were divided into two groups: six mice in the control group and 18 in the experimental group. Conditions of mices` tongues were evaluated after developing epithelial dysplasia using 4-nitroquinoline-l-oxide (4NQO, Sigma Aldrich) solution. Clinical photos were taken with Velscope, which diagnoses oral cancer using an autofluorescent device. Histological analysis was conducted every 4, 8, and 12 weeks for comparison with Velscope images. Results: Oral epithelial dysplasia was observed on tongues treated with 4NQO solution for 8 weeks. As time went by, dysplasia progressed and carcinogenesis was observed. The developing grade of dysplasia was moderate grade. Conclusion: Therefore, after dysplasia develops, lesion cloud could be distinguished by visual inspection and Velscope, although it remains to be confirmed whether Velscope is more beneficial than clinical visualization.
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