Original Article : Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data
분야
의약학 > 내과학
저자
( Moon Young Kim ) , ( Soon Ho Um ) , ( Soon Koo Baik ) , ( Yeon Seok Seo ) , ( Soo Young Park ) , ( Jung Il Lee ) , ( Jin Woo Lee ) , ( Gab Jin Cheon ) , ( Joo Hyun Sohn ) , ( Tae Yeob Kim ) , ( Young Suk Lim ) , ( Tae Hyo Kim ) , ( Tae Hee Lee ) , ( Sun
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대한간학회
간행물정보
Clinical and Molecular Hepatology(대한간학회지) 2013년, 제19권 제1호, 36~44페이지(총9페이지)
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    영문초록
    Background/Aims: While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information regarding hemostasis and the prognosis for GVB. The aim of this study was to determine retrospectively the clinical outcomes of GVB in a multicenter study in Korea. Methods: The data of 1,308 episodes of GVB (males:females=1062:246, age=55.0±11.0 years, mean±SD) were collected from 24 referral hospital centers in South Korea between March 2003 and December 2008. The rates of initial hemostasis failure, rebleeding, and mortality within 5 days and 6 weeks of the index bleed were evaluated. Results: The initial hemostasis failed in 6.1% of the patients, and this was associated with the Child-Pugh score [odds ratio (OR)=1.619; P<0.001] and the treatment modality: endoscopic variceal ligation, endoscopic variceal obturation, and balloon-occluded retrograde transvenous obliteration vs. endoscopic sclerotherapy, transjugular intrahepatic portosystemic shunt, and balloon tamponade (OR=0.221, P<0.001). Rebleeding developed in 11.5% of the patients, and was significantly associated with Child-Pugh score (OR=1.159, P<0.001) and treatment modality (OR=0.619, P=0.026). The GVB-associated mortality was 10.3%; mortality in these cases was associated with Child-Pugh score (OR=1.795, P<0.001) and the treatment modality for the initial hemostasis (OR=0.467, P=0.001). Conclusions: The clinical outcome for GVB was better for the present cohort than in previous reports. Initial hemostasis failure, rebleeding, and mortality due to GVB were universally associated with the severity of liver cirrhosis. (Clin Mol Hepatol 2013;19:36-44)
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