Original Article : Clinical and epidemiological characteristics of Korean patients with hepatitis C virus genotype 6
분야
의약학 > 내과학
저자
( Mun Hyuk Seong ) , ( Ho Kil ) , ( Jong Yeop Kim ) , ( Sang Soo Lee ) , ( Eun Sun Jang ) , ( Jin Wook Kim ) , ( Sook Hyang Jeong ) , ( Young Seok Kim ) , ( Si Hyun Bae ) , ( Youn Jae Lee ) , ( Han Chu Lee ) , ( Hae Sun Yun ) , ( Byung Hak Kang ) , ( Ki S
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대한간학회
간행물정보
Clinical and Molecular Hepatology(대한간학회지) 2013년, 제19권 제1호, 45~50페이지(총6페이지)
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    영문초록
    Background/Aims: The distribution of hepatitis C virus (HCV) genotypes varies geographically. In Korea, genotypes 1 and 2 comprise more than 90% of HCV infections, while genotype 6 is very rare. This study compared the clinical and epidemiological characteristics of patients with genotype 6 HCV infection with those infected with HCV genotypes 1 and 2. Methods: This was a prospective, multicenter HCV cohort study that enrolled 1,173 adult patients, of which 930 underwent HCV genotype analysis, and only 9 (1.0%) were found to be infected with genotype 6 HCV. The clinical and epidemiological parameters of the genotypes were compared. Results: The patients with genotype 6 HCV had a mean age of 41.5 years, 77.8% were male, and they had no distinct laboratory features. A sustained virologic response (SVR) was observed in four (67%) of six patients who received antiviral therapy. Risk factors such as the presence of a tattoo (n=6, 66.7%), more than three sexual partners (n=3, 33.3%), and injection drug use (n=3, 33.3%) were more common among genotype 6 patients than among genotypes 1 or 2. Conclusions: The epidemiology and treatment response of patients infected with genotype 6 HCV differed significantly from those with genotypes 1 or 2, warranting continuous monitoring. (Clin Mol Hepatol 2013;19:45-50)
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