ORINGINAL ARTICLE : Insights into the Transforming Growth Factor-βSignaling Pathway in Cutaneous Melanoma
분야
의약학 > 피부과학
저자
caroleyolandeperrot , delphinejavelaud , alainmauviel
발행기관
대한피부과학회
간행물정보
Annals of Dermatology 2013년, 제25권 제2호, 135~144페이지(총10페이지)
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27728764.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Transforming growth factor-β (TGF-β) is a pleiotropic growth factor with broad tissue distribution that plays critical roles during embryonic development, normal tissue homeostasis, and cancer. While its cytostatic activity on normal epithelial cells initially defined TGF-β signaling as a tumor suppressor pathway, there is ample evidence indicating that TGF-β is a potent pro-tumorigenic agent, acting via autocrine and paracrine mechanisms to promote peri-tumoral angiogenesis, together with tumor cell migration, immune escape, and dissemination to metastatic sites. This review summarizes the current knowledge on the implication of TGF-β signaling in melanoma.
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