Review : A New Technical Approach to Monitor the Cellular Physiology by Atomic Force Microscopy
분야
의약학 > 기타(의약학)
저자
( Kyung Hwan Jeong ) , ( Sang Ho Lee )
발행기관
대한전해질학회
간행물정보
Electrolytes & Blood Pressure 2012년, 제10권 제1호, 7~11페이지(총5페이지)
파일형식
0v900245.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Atomic force microscopy (AFM) has become an important medical and biological tool for non-invasive imaging and measuring the mechanical changes of cells since its invention by Binnig et al. AFM can be used to investigate the mechanical properties of cellular events in individual living cells on a nanoscale level. In addition, the dynamic cellular movements induced by biochemical activation of specific materials can be detected in real time with three dimensional resolution. Force measurement with the use of AFM has become the tool of choice to monitor the mechanical changes of variable cellular events. In addition, the AFM approach can be applied to measure cellular adhesion properties. Moreover, the information gathered from AFM is important to understanding the mechanisms related to cellular movement and mechanical regulation. This review will discuss recent contributions of AFM to cellular physiology with a focus on monitoring the effects of antihypertensive agents in kidney cells.
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