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| 영문초록 |
| Objectives: To provide information on the safety of ACM, we carried out a single oral dose-increasing toxicity and 4-weeks repeated oral dose determining test of ACM in beagle dogs. Methods: In a single oral dose-increasing toxicity test, beagles were treated with ACM orally increasing dose level (1,000, 2,000, 5,000 mg/㎏) at interval of 3 days. After administration, signs of toxicity were observed for two weeks. In 4-weeks repeated oral dose determinating test, beagles were treated with ACM with oral dose 500, 1,000, 2,000 mg/kg for 4 weeks. Mortality, clinical signs, body weight changes, food consumption, urinalysis, hematological and biochemical parameters, organ weights, necropsy findings, and histological findings were monitored during the study period. Results: In a single oral dose-increasing toxicity test, we found no mortality, abnormalities in clinical signs, body weight, and necropsy findings during the study period. In 4-weeks repeated oral dose determinating test, we found no mortality, abnormalities in clinical signs, body weight, food consumption, urinalysis, hematological and biological parameters, gross findings, organ weights, necropsy findings, and histopathological findings in any of the beagles tested. Conclusions: The results obtained in these studies suggest that maximum tolerated dose (MTD) of ACM in male and female beagle dogs was supposed to be over 5,000 mg/kg. For the future studies of toxicity, it is advisable that high dose and low dose are set at 2000 mg/kg and 500 mg/kg, respectively. |
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| 도움말 |
| 본 논문은 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다. |
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| 추천자료 |
| [영양지원] 경장영양지원(경구보충, 경관급식, 경관영양액, 경관영양, 경관급식 투여방법, 경관급식의 합병증 및 치료방안) |
| 생물학적 치료 레포트 |
| [의약품][제약][약][약물][제약산업]의약품과 공공성, 의약품과 안정성 및 유효성, 의약품과 유사의약품, 의약품과 브랜드, 의약품과 약물전달시스템, 의약품과 기술협력, 의약품과 초국적 제약자본 분석 |
| [간호학] 투상간의 병동 생활 |
| 고위험신생아, 고위험신생아약물투약, 고위험신생아감염, 고위험신생아감염예방, 고위험신생아간호 |
| [간호학, 항암요법, 항암요법 case study] chemotherapy |
| [간호학 실습레포트]자궁근종에 대한 케이스 스터디 |
| [의약 생명공학] 생물 독성에 관해서 |
| 신생아 가사 간호과정 |
| [A+]아동간호학 실습, case study, Other otitis externa, 외이도염, 케이스 스터디, 간호진단 3개 |
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| 저작권 정보 |
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| 본 학술논문은 한국학술정보㈜ 각 학회간에 저작권 계약이 체결된 것으로 HAPPY학술이 제공하고 있습니다. 본 저작물을 불법적으로 이용시는 법적인 제재가 가해질 수 있습니다. |
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분야
38600828.pdf 
