ORiginal Article : Levofloxacin, Metronidazole, and Lansoprazole Triple Therapy Compared to Quadruple Therapy as a Second-Line Treatment of Helicobacter pylori Infection in Korea
의약학 > 내과학
( Ji Yoon Moon ) , ( Gwang Ha Kim ) , ( Hyun Seok You ) , ( Bong Eun Lee ) , ( Dong Yeop Ryu ) , ( Jae Hoon Cheong ) , ( Jung Im Jung ) , ( Jae Hoon Jeong ) , ( Chul Soo Song ) , ( Geun Am Song )
Gut and Liver 2013년, 제7권 제4호, 406~410페이지(총5페이지)
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    Background/Aims: Several rescue therapies have been rec¬ommended to eradicate Helicobacter pylori infection in pa¬tients with a failure of first-line eradication therapy, but they still fail in more than 20% of cases. The aim of this study was to evaluate the efficacy and safety of levofloxacin, metroni-dazole, and lansoprazole (LML) triple therapy relative to qua¬druple therapy as a second-line treatment. Methods: In total, 113 patients who failed first-line triple therapy for H. pylori infection were randomly assigned to two groups: LML for 7 days and tetracycline, bismuth subcitrate, metronidazole and lansoprazole (quadruple) for 7 days. Results: According to intention-to-treat analysis, the infection was eradicated in 38 of 56 patients (67.9%) in the LML group and 48 of 57 (84.2%) in the quadruple group (p=0.042). Per-protocol analysis showed successful eradication in 38 of 52 patients (73.1%) from the LML group and 48 of 52 (92.3%) from the quadru¬ple group (p=0.010). There were no significant differences in the adverse effects in either treatment group. Conclusions: LML therapy is less effective than quadruple therapy as a second-line treatment for H. pylori infection. Therefore, qua¬druple therapy should be considered as the primary second-line strategy for patients experiencing a failure of first-line H. pylori therapy in Korea.
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