ORiginal Article : Durability of Sustained Virologic Response in Chronic Hepatitis C
분야
의약학 > 내과학
저자
( Ahmet Uyanikoglu ) , ( Sabahattin Kaymakoglu ) , ( Ahmet Danalioglu ) , ( Filiz Akyuz ) , ( Fatih Ermis ) , ( Binnur Pinarbasi ) , ( Kadir Demir ) , ( Fatih Besisik ) , ( Yilmaz Cakaloglu )
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대한간학회
간행물정보
Gut and Liver 2013년, 제7권 제4호, 458~461페이지(총4페이지)
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    Background/Aims: The aim of this study is to investigate the rate of sustained virologic response (SVR) in chronic hepatitis C patients receiving antiviral treatment. Methods: The files of patients with chronic hepatitis C treated with interferon±ribavirin between 1995 and 2009 were reviewed retrospectively. Six months after the end of treatment, pa¬tients with negative hepatitis C virus (HCV)-RNA (<50 IU/mL, as determined by the polymerase chain reaction method) were enrolled in the study. Results: The mean age of 196 patients (89 males) was 46.13±11.10 years (range, 17 to 73 years). In biopsies, the mean stage was 1.50±0.94; his¬tological activity index was 7.18±2.43. In total, 139 patients received pegylated interferon (IFN)+ribavirin, 21 patients re¬ceived classical IFN+ribavirin, and 36 patients received IFN alone. The HCV genotypes of 138 patients were checked: 77.5% were genotype 1b, and 22.5% were other genotypes. After achievement of SVR, the median follow-up period was 33.5 months (range, 6 to 112 months), and in this period relapse was only detected in two patients (1.02%) at 18 and 48 months after treatment. Conclusions: In total, 98.9% of patients with SVR in chronic hepatitis C demonstrated truly durable responses over the long-term follow-up period of 3 years; relapsed patients had intermittent or low-grade vire¬mia.
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