ORiginal Article : Hepatitis B Core Antigen Expression in Hepatocytes Reflects Viral Response to Entecavir in Chronic Hepatitis B Patients
분야
의약학 > 내과학
저자
( Jeong Guil Lee ) , ( Seong Gyu Hwang ) , ( Harry Yoon ) , ( Myung Su Son ) , ( Dae Young Kim ) , ( Jeong Hwan Yoo ) , ( Kwang Il Kim ) , ( Kyu Sung Rim )
발행기관
대한간학회
간행물정보
Gut and Liver 2013년, 제7권 제4호, 462~468페이지(총7페이지)
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27405927.pdf [무료 PDF 뷰어 다운로드]
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    Background/Aims: Hepatitis B core antigen is known to be a major target for virus-specific T cells and also reflects the progression of liver dissease and viral replication. Hepatitis B core antigen expression in hepatocytes leads to altered histological activity, viral replication, and immune response. The purpose of this study is to evaluate whether the topo¬graphical distribution of hepatitis B core antigen expres¬sion can predict the viral response to entecavir in patients with chronic hepatitis B. Methods: We enrolled 91 patients with treatment-naive chronic hepatitis B. All the patients underwent liver biopsy, and the existence and pattern of hepatitis B core antigen evaluated by immunohistochemis¬try. All patients received 0.5 mg of entecavir daily following a liver biopsy. We checked the viral response at 3, 6, and 12 months during antiviral therapy. Results: Of the 91 patients, 64 (70.3%) had hepatitis B core antigen expression. Of the subcellular patterns, the mixed type was dominant (n=48, 75%). The viral response was significantly higher in the hepa¬titis B core antigen-negative group than in the hepatitis B core antigen-positive group (88.9% and 54.7%, respectively; p=0.001) after 12 months of entecavir therapy. Conclu¬sions: Chronic hepatitis B patients who are hepatitis B core antigen-negative have a better response to entecavir therapy than do hepatitis B core antigen-positive patients.
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