ORiginal Article : Radiotherapy Prolongs Biliary Metal Stent Patency in Malignant Pancreatobiliary Obstructions
의약학 > 내과학
( Semi Park ) , ( Jeong Youp Park ) , ( Seung Min Bang ) , ( Seung Woo Park ) , ( Jae Bock Chung ) , ( Si Young Song )
Gut and Liver 2013년, 제7권 제4호, 480~485페이지(총6페이지)
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    Background/Aims: Biliary stenting is the most effective decompressive method for treating malignant biliary obstruc¬tive jaundice. Although the main cause of stent occlusion is tumor growth, few studies have investigated whether stent patency is affected by the combination of cancer-treatment modalities. The aim of this study was to evaluate the effects of local radiotherapy on metal-stent patency in patients with malignant biliary obstruction. Methods: Patients who underwent self-expandable biliary metallic stenting for ma¬lignant biliary obstruction from 1999 to 2007 were included. Forty patients received chemotherapy and radiation therapy (radiation group, RG), and 31 patients received only chemo¬therapy (nonradiation group, NRG). Results: The cumulative median stent patency was significantly longer in the RG than in the NRG (17.7 months; 95% confidence interval [CI], 1.8 to 33.6 months vs 8.7 months; 95% CI, 4.9 to 12.5 months; p=0.025). Stent occlusion caused by tumor growth or stent migration occurred in two (5%) and three (7.5%) cases in the RG and in six (19.3%) and two (6.5%) cases in the NRG, respectively. Conclusions: The patency of biliary metal stents in pancreatobiliary cancer patients who receive chemora¬diation therapy is significantly longer than that in patients who do not receive radiotherapy, which suggests that local cancer control significantly affects stent patency.
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