Wilson`s disease (WD) is an autosomal recessive inherited disorder of copper metabolism that results in the accumula￢tion of copper in the body and primarily in the liver, brain, and cornea. Copper is a toxic metal and might be associated with cancer induction. Most malignancies associated with WD are hepatocellular carcinoma and cholangiocarcinoma. Other intra-abdominal malignancies have been only rarely reported. To our knowledge, this is the first report to sug￢gest that patients with WD may be vulnerable to a malignant change in the colonic mucosa during long-term copper che￢lating therapy. We report a case of colonic adenocarcinoma in a patient with WD and review the related literature.