ORiginal Article : Lichen Planus Is an Uncommon Cause of Nonspecific Proximal Esophageal Inflammation
의약학 > 내과학
( Matthew S Linton ) , ( Liena Zhao ) , ( Xianyong Gui ) , ( Martin Storr ) , ( Christopher N Andrews )
대한소화기기능성질환·운동학회(구 대한소화관운동학회)
Gut and Liver 2013년, 제7권 제4호, 401~405페이지(총5페이지)
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    Background/Aims: Esophageal lichen planus (LP) has been described as a cause of nonspecific esophagitis that may cause dysphagia, but its incidence is unknown. We aimed to estimate the incidence of esophageal LP in a defined geographic region and describe the clinical characteristics of affected patients. Methods: A histopathology database for a population of 1 million people was searched for all esophageal mucosal biopsy results over an 8-year period. Cases showing inflammation or abnormalities without a diagnosis after three or more biopsies were reviewed for findings of LP. Results: Of 13,589 esophageal biopsies, only one received a diagnosis of LP. Seven patients (four male; mean age, 59 years; range, 39 to 76 years) were identified as having chronic dysphagia and nonspecific proximal esophagitis for which no diagnosis could be made. All patients had proximal inflammation, and six of seven had full-thickness lymphocytic infiltration. Elongation of the lamina propria papillae was noted in all patients, whereas six patients had parakeratosis and ballooning. Only one patient had findings potentially consistent with, but not sufficient for, a diagnosis of esophageal LP. Conclusions: Esophageal LP appears to be extremely uncommon in this North American population, and esophageal biopsy alone is likely not sufficient to establish a diagnosis of LP. (Gut Liver 2013; 7:401-405)
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