ORiginal Article : Proteomic Identification of Proteins Suggestive of Immune-Mediated Response or Neuronal Degeneration in Serum of Achalasia Patients
분야
의약학 > 내과학
저자
( Seon Kyo Im ) , ( Mari Yeo ) , ( Kwang Jae Lee )
발행기관
대한소화기기능성질환·운동학회(구 대한소화관운동학회)
간행물정보
Gut and Liver 2013년, 제7권 제4호, 411~416페이지(총6페이지)
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19201988.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Background/Aims: The primary pathophysiologic abnormality in achalasia is known to be a loss of inhibitory myenteric ganglion cells, which may result from an immune mediated response or neuronal degeneration. The aim of this study was to identify proteins suggestive of an immune mediated response or neuronal degeneration in the serum of achalasia patients using a proteomic analysis. Methods: Blood samples were collected from five symptomatic achalasia patients and five sex- and age-matched healthy controls. Serum proteomic analysis was conducted, and the protein spots were identified using matrix-assisted laser desorption ionization/time of flight and a proteomics analyzer. The serum level of C3 was measured by enzyme-linked immunosorbent assay in nine patients with achalasia and 18 sex- and age-matched healthy controls. Results: Of the 658 matched protein spots, 28 spots were up-regulated over 2-fold in the serum from achalasia patients compared with that from controls. The up regulated proteins included complement C4B5, complement C3, cyclin-dependent kinase 5, transthyretin, and alpha 2 macroglobulin. The serum levels of C3 in achalasia patients were significantly higher than those of controls. Conclusions: The serum proteomic analysis of achalasia patients suggests an immune-mediated response or neuronal degeneration. Further validation studies in larger samples and the esophageal tissue of achalasia patients are required. (Gut Liver 2013; 7:411-416)
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