ORiginal Article : Investigation of Interleukin-10 Promoter Polymorphisms and Interleukin-10 Levels in Children with Irritable Bowel Syndrome

분야: 의약학 > 내과학
저자: ( Man Chin Hua ) , ( Hsun Chin Chao ) , ( Tsung Chieh Yao ) , ( Ming Wei Lai ) , ( Jing Long Huang ) , ( The Patch Study Group )
발행기관: 대한소화기기능성질환·운동학회(구 대한소화관운동학회)
간행물정보: Gut and Liver 2013년, 제7권 제4호, 430~436페이지(총7페이지)
파일형식: 19201991.pdf [무료 PDF 뷰어 다운로드]
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연관 논문

Original Article : Polymorphisms of the Serotonin Transporter Gene and G-Protein β3 Subunit Gene in Korean Children with Irritable Bowel Syndrome and Functional Dyspepsia

Disorders of Gastrointestinal Motility & Sensation : Genetic Association Between G Protein B3 Subunit, IL-10, TNF-A Gene Polymorphisms And Irritable Bowel Disease In Korean

영문초록

Background/Aims: The aim of this study was to investigate whether genetic variations at positions -1082, -819, and 592 in the interleukin (IL)-10 promoter affect IL-10 production in children with irritable bowel syndrome (IBS). Methods: Ninety-four children with IBS and 102 children as healthy controls (HCs) were enrolled. Genomic DNA was extracted, and IL-10 -1082, -819, and -592 polymorphisms were detected by direct sequencing from all participants. Peripheral blood mononuclear cells (PBMCs) from 46 IBS children and 38 HCs were isolated and cultured with and without 5 ng/mL Escherichia coli lipopolysaccharide (LPS). IL-10 levels in the culture supernatants were measured by enzyme-linked immunosorbent assay. Results: There were no significant differences in the distribution of IL-10 -1082, -819, and -592 polymorphisms or in the allele and haplotype frequencies between IBS children and HCs. PBMCs from children with IBS had significantly lower IL-10 levels after LPS stimulation than PBMCs from HCs (p=0.011), however, LPS-induced IL-10 levels in PBMCs with different genotypes of -819 and 592 polymorphisms were not significantly different between IBS patients and HCs. Conclusions: Although significantly lower LPS-induced IL-10 production by PBMCs was noted, it is unlikely that IL-10 production was fully genetically determined in our IBS children. ClinicalTrials.gov identifier: NCT01131442. (Gut Liver 2013; 7:430-436)

#Irritable bowel syndrome # Child # Interleukin-10 # Interleukin-10 gene polymorphisms

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