JNM : Original Article ; Specific Movement of Esophagus During
의약학 > 내과학
( Transient Lower Esophageal Sphincter ) , ( Relaxation In Gastroesophageal Reflux Disease ) , ( Hoon Il Kim ) , ( Su Jin Hong ) , ( Jae Pil Han ) , ( Jung Yeon Seo ) , ( Kyoung Hwa Hwang ) , ( Hyo Jin Maeng ) , ( Tae Hee Lee ) , ( Joon Seong Lee )
대한소화기기능성질환·운동학회(구 대한소화관운동학회)
Journal of Neurogastroenterology and Motility 2013년, 제19권 제3호, 332~337페이지(총6페이지)
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    Background/Aims Transient lower esophageal sphincter relaxation (TLESR) is the main mechanism of gastroesophageal reflux disease (GERD). The aim of this study was to investigate the characteristics of transient lower esophageal sphincter movement in patients with or without gastroesophageal reflux by high-resolution manometry (HRM). Methods From June 2010 to July 2010, we enrolled 9 patients with GERD (GERD group) and 9 subjects without GERD (control group), prospectively. The manometry test was performed in a semi-recumbent position for 120 minutes following ingestion of a standardized, mixed liquid and solid meal. HRM was used to identify the frequency and duration of TLESR, esophageal shortening length from incomplete TLESR, upper esophageal sphincter (UES) response, and the related esophageal motor responses during TLESR. Results TLESR occurred in 33 in the GERD group and 34 in the control group after 120 minutes following food ingestion. Duration of TLESR and length of esophageal shortening did not differ between 2 groups. UES pressure increase during TLESR was mostly detected in patients with GERD, and UES relaxation was observed frequently in the control group during TLESR. TLESR related motor responses terminating in TLESR were predominantly observed in the control group. Conclusions Increased UES pressure was noted frequently in the GERD group, suggesting a mechanism for preventing harmful reflux, which may be composed mainly of fluid on the larynx or pharynx. However, patients with GERD lacked the related motor responses terminating in TLESR to promote esophageal emptying of refluxate. (J Neurogastroenterol Motil 2013; 19:332-337)
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