Work-family conflict is an important issue in the hotel human resource management. The study examined the structural relationships among work-family conflict, social support, burnout and job satisfaction. To test the hypotheses among the constructs, data were collected from 221 hotel employees at 7 five-star hotels in Jeju province on November 2010. Results of a structural equation model analysis showed that respondents` perception on their experience of work-family conflict were negatively associated with their perception of social support and job satisfaction. In contrast, the respondents` perception of work-family conflicted were positive related to the level of burnout. Results also indicated that the respondents` experience of social support tended to mitigate the level of burnout and enhance the level of job satisfaction. Implications for human resources manager and employee stress management were discussed.