Telomere Length of Tumor Tissues and Survival in Patients with Early Stage Non-Small Cell Lung Cancer
분야
의약학 > 내과학
저자
이용훈 , ( Hyo Sung Jeon ) , ( Eung Bae Lee ) , ( Seung Soo Yoo ) , ( Shin Yup Lee ) , ( Jaehee Lee ) , ( Seung Ick Cha ) , ( Chang Ho Kim ) , ( Jae Yong Park )
발행기관
대한결핵 및 호흡기학회
간행물정보
대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 150(총1페이지)
파일형식
0y909808.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    1,000원
    적립금
    30원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    영문초록
    Introduction: Telomere shortening leads to genomic instability that drives oncogenesis through the activation of telomerase and the generation of other mutations necessary for tumor progression. This study was conducted to determine the impact of telomere shortening on the survival of patients with early stage non-small cell lung cancer (NSCLC). Methods: Relative telomere length in tumor tissues was measured by quantitative polymerase chain reaction in 164 patients with surgically-resected NSCLC. The association between telomere length and overall survival (OS) and disease-free survival (DFS) was analyzed. Results: When the patients were categorized into quartiles based on telomere length, those patients with the 1st quartile (shortest) of telomere length had a significantly worse OS and DFS compared to patients with the 2nd to the 4th quartiles of telomere length (adjusted hazard ratio for OS=2.67, 95% confidence interval=1.50-4.75, p=0.001; and adjusted hazard ratio for DFS=1.92, 95% confidence interval=1.17-3.14, p=0.01). An association between telomere length and survival outcome was more pronounced in squamous cell carcinomas than adenocarcinomas (p-value of test for homogeneity for OS and DFS=0.05 and 0.02, respectively). Conclusion: Telomere length of tumor tissues is an independent prognostic factor in patients with surgically resected early stage NSCLC.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.