Association between Elevated Pleural IL-33 Levels and Tuberculous Pleurisy

분야: 의약학 > 내과학
저자: 황기은 , 이경선 , 박도심 , 김학렬 , 정은택
발행기관: 대한결핵 및 호흡기학회
간행물정보: 대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 154(총1페이지)
파일형식: 0y909815.pdf [무료 PDF 뷰어 다운로드]
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연관 논문

PE-106 : Pleural fluid ADA level in tuberculous pleurisy can be low in old age, critically ill patients with multi-organ failure

원저 : Flow Cytometer 를 이용한 , 결핵환자의 말초혈액 및 늑막저류액에서의 T - 임파구아형의 변화에 관한 연구 ( Flow Cytometric Study of the Change of T - Lymphocytic Subpopulation in the Peripheral Blood and Pleural Effusion from Tuberculous Patients )

원저 : 결핵성 흉막염에서 Interferon - gamma , Adenosine Deaminase 와 Carcinoembryonic Antigen 의 진단적 가치 ( Diagnostic Significance of Interferon - gamma , Adenosine Deaminase , and Carcinoembryonic Antigen in Tuberculous Pleural Effusion )

OP-015 : Serum interleukin-33 level was associated with previous acute exacerbation history in COPD patients

Pleural Fluid Characteristics of Pleuropulmonary Paragonimiasis Masquerading as Tuberculous Pleurisy

영문초록

Background: Interleukin (IL)-33 produces interferon-γ (IFN-γ) which plays a crucial role in Mycobacterium tuberculosis induced pleural responses. We aimed to identify the association between pleural IL-33 levels and tuberculous pleurisy and their diagnostic value. Methods: Pleural IL-33, ST2 (a receptor of IL-33), adenosine deaminase (ADA), and IFN-γ, as well as serum IL-33 and ST2 were measured in 220 patients with pleural effusions (PEs; malignant [MPEs], parapneumonic [PPEs], tuberculous [TPEs], and cardiogenic [CPEs]). Results: Pleural and serum IL-33 levels were highest or tended to be higher in TPEs than in other PEs. The median pleural fluid-to-serum IL-33 ratio was higher in TPE cases (≥0.91) than in other PE cases (≤0.56). Pleural IL-33 correlated with pleural ADA and IFN-γ. However, the diagnostic accuracies of pleural IL-33 (0.74) and pleural fluid-to-serum IL-33 ratio (0.75) were lower than that of ADA (0.95) or IFN-γ (0.97). Pleural ST2 levels in MPEs were higher than in TPEs. SerumST2 levels did not differ between the groups. Conclusions: We identified an association between elevated pleural IL-33 levels and tuberculous pleurisy. However, we recommend conventional pleural markers (ADA or IFN-γ) as diagnostic markers of TPE.

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