Association between Idiopathic Pulmonary Fibrosis and Coronary Artery Disease: a Case-control Study and Cohort Analysis

분야: 의약학 > 내과학
저자: 김원영 , 목예진 , 백수진 , 윤영덕 , 지선하 , 김동순
발행기관: 대한결핵 및 호흡기학회
간행물정보: 대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 167(총1페이지)
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Original Article : The Clinical Assessment of Protease-Activated Receptor-2 Expression in Inflammatory Cells from Peripheral Blood and Bronchoalveolar Lavage Fluid in Idiopathic Pulmonary Fibrosis

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영문초록

Background: Although the increased risk of coronary artery disease (CAD) in the patients with idiopathic pulmonary fibrosis (IPF) has been reported, there was no detailed information on the risk factors for CAD in IPF. The aim of this study was to investigate the prevalence of CAD in IPF with analysis of other risk factors. Methods: The subjects were 460 patients (mean age at diagnosis, 65 years; 79% male; 74% current or ex-smoker) diagnosed as IPF at Asan Medical Center and 1,925 controls matched with age, sex, smoking habits, and date of IPF diagnosis obtained from Korea Heart Study. Cardiovascular risk factors and prevalence of CAD in both groups were compared and the incidence of newly developed CAD during follow-up was also analyzed. Results: The IPF group was more diabetic, and the control group had a higher proportion of hypertension and hypercholesterolemia. The prevalence of CAD in IPF group (7.2%) was two times higher than that of control group (3.4%). Multivariate analysis revealed that age (OR, 1.04; 95% CI, 1.01-1.07), hypertension (OR, 1.94; 95% CI, 1.23-3.05), hypercholesterolemia (OR, 5.11; 95% CI, 3.15-8.29), and IPF (OR, 3.94; 95% CI, 2.44-6.37) were significant risk factors for CAD. During the follow-up period (median: 2.5 years for IPF and 4.4 years for controls), the incidence of newly diagnosed CAD was higher in the patients with IPF (4%) compared to controls (2.7%) (RR, 3.08; 95% CI, 1.70-5.58). Conclusions: IPF itself seems to be an independent risk factor for CAD after the adjustment of age, hypertension, diabetes and hypercholesterolemia.

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