Pleural Fluid Pentraxin-3 and Calprotectin for the Differential Diagnosis of Pleural EffusionsPleural Fluid Pentraxin-3 and Calprotectin for the Differential Diagnosis of Pleural Effusions
의약학 > 내과학
이혜연 , 여창동 , 김진우 , 조미란 , 박찬권 , 강지영 , 이상학 , 김영균 , 김관형 , 김승준
대한결핵 및 호흡기학회
대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 171(총1페이지)
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    Background: Conventional biomarkers cannot always establish the cause of pleural effusions, so alternative tests permitting rapid and accurate diagnosis are required. The primary aim of this study was to assess the ability of pentraxin-3 and calprotectin to diagnose pleural effusions and compare their efficacy to that of other conventional markers. Methods: We studied 128 patients with pleural effusions, classified as transudates and exudates including malignant, tuberculous, and parapneumonic effusions (MPE, TPE and PPE) and empyema. The pleural fluid levels of pentraxin-3 (PTX3), calprotectin, C-reactive protein (CRP), soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT) and lactate were assessed. Results: Calprotectin, CRP, PCT, and lactate levels were significantly higher in patients with exudates than transudates. PTX3 yielded the most favorable sensitivity and specificity to discriminate PPE from MPE or TPE, providing an AUC=0.74 (95%CI 0.63-0.84), a sensitivity=62.07%, and a specificity=81.08%, with a cut-off point of 25.00 ng/ml. Conclusion: Our data suggest that calprotectin was limited in its ability to differentiate between exudative pleural effusions of different origins. However, PTX3 may allow improved differentiation of PPE from MPE or TPE compared to the previously identified biomarkers CRP, sTREM-1, and PCT.
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