Background: Flexible bronchoscopy is a widely used medical procedure performed by pulmonologist. Not only for diagnosis, but also for therapeutic interventions, it has achieved widespread use and is now performed in a diversity of therapeutic plans. Patients with airway obstruction may need endobronchial intervention to relieve the associated symptoms and signs. We report our experience of interventional bronchoscopy with regard to outcomes, complications and survival. Methods: A total of 47 patients were treated with 68 endobronchial procedures at our department between December 2009 and August 2012. Patients with endobronchial obstruction treated with interventional flexible bronchoscopy were enrolled. Cryotherapy, endobronchial electrocautery were performed under continuous sedation with midazolam. Results: The mean age of enrolled patients was 65.7 years and there was a male (89.1%) dominance. Among the malignant tumor, Squamous cell carcinoma was most common tumor (69.7%) and Right bronchus was most common obstruction site (48.5%). The success rate of interventional flexible bronchoscopic recanalization was 94.8% at malignant lesions and chest image improvement after intervention was 85.4%. Mean interventional time at malignancy was 26.1minutes. Serious complications such as bleeding, serever hypoxemia, bronchospasm were rare. Conclusions: Interventional flexible bronchoscopy is a safe method for palliation for endobronchial obstruction causing malignancy or benign lesion, an effective and less expensive procedure and serious complications are rare.