Plasma Cytokine Analysis between Steroid Responders and Steroid Non-responders in Asthmatics
의약학 > 내과학
박종숙 , ( Young Suk Choi ) , ( An Soo Jang ) , ( Soo Hyun Kim ) , ( Jeong Seok Heo ) , ( Ji Da Choi ) , ( Si Young Lee ) , ( Eun Som Kim ) , ( Yoo Jung Lim ) , ( Choon Sik Park )
대한결핵 및 호흡기학회
대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 191(총1페이지)
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    Background: Inhaled corticosteroids (ICSs) have revolutionized the treatment of asthma and are now the mainstay of therapy for patients with chronic asthma. Interleukin (IL)-33 is a recently characterized IL-1 family cytokine and found to be expressed in inflammatory diseases, including severe asthma and inflammatory bowle disease. IL-32 is a proinflammatory cytokine originally described as a transcript termed NK4 found in activated natural killer (NK) cells and T lymphocytes. analysis of IL-32 and IL-33 cytokine may be important for understanding the pathobiology of steroid asthma at the protein levels. Objective We studied to identify biomarkers in steroid non-responder asthma as comparing protein profiles in plasma between steroid non-responders and steroid responers in asthmatics. Methods: We investigated that the IL-1b, IL-32 and IL-33 level of plasma between nomal control (n=10), steroid non responders (n=14) and steroid responders (n=20) in non-smoker asthmatics by ELISA. Results: We found that IL-33 level was lower significantly in the steroid non-responders (n=14) than the steroid responders(n=20) in asthmatics (p=0.01). But the level of IL-1b, IL-32 had no significant differences between the steroid responders(n=20) and the steroid non-responders (n=14) in asthmatics (p>0.05). Conclusion: This study suggested that the IL-33 level of plasma might be a biomarker of steroid non- respondes in asthmatics.
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