Mannitol Challenge Test, Sputum Eosinophils and Exhaled Nitric Oxide (FENO) for Diagnosis of Asthmaw

분야: 의약학 > 내과학
저자: 최종현 , 허규영 , 오지연 , 심재겸 , 이은주 , 민경훈 , 이승룡 , 이상엽 , 심재정 , 신철 , 인광호 , 강경호
발행기관: 대한결핵 및 호흡기학회
간행물정보: 대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 192(총1페이지)
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연관 논문

S-664 Clinical utility of fractional exhaled nitric oxide measurement for chronic cough: A meta-analysis

S-660 Relationship with FENO level and airway responses in patients with suspect bronchial asthma

F-29 Prevalence of Airway Disease in Patients with Idiopathic Pulmonary Fibrosis

Clinical Features of Chronic Obstructive Pulmonary Disease with High Fractional Exhaled Nitric Oxide

Original Articles : Relationship between Exhaled Nitric Oxide and Levels of Asthma Control in Asthma Patients Treated with Inhaled Corticosteroid

영문초록

Rationale: Mannitol challenge tests are used to identify individuals of bronchial asthma. Exhaled nitric oxide (FENO) and sputum eosinophils are also used as noninvasive diagnostic tools for bronchial asthma. Therefore, we purposed to identify those diagnostic findings in patients with clinical diagnosis of bronchial asthma. Methods: Total 463 subjects who were suspected as having bronchial asthma were enrolled and their clinical data was analyzed. Skin prick test with common inhalant allergens was done to identify atopic status. Serum total IgE levels were measured by immunoCAP system. They were performed mannitol challenge test (Aridol?, Pharmaxis). Their induced sputa were analyzed for differential count. FENO was measured by NIOX MINO (Aerocrine AB, Sweden) at that time. Results: Mean age of the subjects was 45.60±14.39 years and 44.5% (206 subjects) were male. Atopy prevalence was 49.8%, and mean total IgE level was 195.91±323.78 IU/L. Ninety four subjects (21.2%) have positive responses in mannitol challenge tests. One hundred forty six (31.5%) out of all subjects had clinical diagnosis of bronchial asthma. Among them, mean FENO level was 47.28±37.67 and sputum eosinophils were 4.68±13.52. The levels of airway hyperresponsiveness were significantly correlated with FENO and sputum eosinophils (P＜0.001 for FENO, P=0.001 for sputum eosinophils). Conclusion: Theses findings suggest that FENO and sputum eosinophils may have a complementary role in diagnosis of bronchial asthma to mannitol challenge test.

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