Positive Correlation between Serum Adiponection and Pulmonary Function in a Community-based Elderly Cohort
의약학 > 내과학
이홍열 , 이태훈 , 박지영 , 임효정 , 박종선 , 조영재 , 이재호 , 이춘택 , 윤호일 , 임수 , 장학철
대한결핵 및 호흡기학회
대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 194(총1페이지)
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    Background: Adiponectinis a predominantly anti-inflammatory protein that may play a role in inflammatory pulmonary conditions such as asthma and chronic obstructive pulmonary disease (COPD). Previous studies found that lower serum adiponectin concentration was associated with lower pulmonary function in young adults. To investigate this association in elderly people was the main objective of this study. Method: We investigated the association between results of pulmonary function tests and adiponectin level in a community-based cohort of elderly people (>65 years), the Korean Longitudinal Study on Health and Aging (KLoSHA). Result: A total of 579 participants performed pulmonary function tests. Gender ratio was 275:304 (M:F) and their median age was 71 years (range 65-95). Average value of percent of predicted forced vital capacity (%FVC) was 95.23%, and that of predicted forced expiratory volume in one second (%FEV1) was 108.15%. After adjusting for BMI, %FVC and %FEV1 were positively associated with serum adiponectin (r=0.127, p=0.003 for %FVC, r=0.160, p<0.001 for %FEV1). No association was found between serum adiponectin concentration and FEV1/FVC ratio or peak expiratory flow rate (PEFR). Conclusion: Serum adiponectin concentration is positively correlated with lung function in elderly people independent of obesity.
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