Background: Active smoking is widely acknowledged as the single most important risk factor for COPD. However, it is still controversial that the exposure to secondhand smoking on never-smoker is also a risk factor. In this study, we investigated association of passive smoking exposure to never smokers and occurrence of COPD. Method: This study was based on the data obtained from the Korean National Health and Nutrition Examination Surveys (KNHANES) conducted from 2008 to 2010. Using nationwide stratified random sampling, participants who were aged 40 years or over and available for lung function tests were included in the analysis. Never-smokers were selected and duration of exposure to passive smoking were measured based on the questionnaire of KNHANES. Result: The prevalence of COPD based on Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria was 6.67% (men, 12.96%; women, 5.77%) in never-smokers. We divided the never-smokers with exposure to secondhand smoke into two groups, with COPD and without COPD. The former group was older than the latter (58.84 vs. 52.18, P=0.0002), had higher prevalence of asthma and TB (12.61% vs. 3.14%, P=0.0002; 17.62% vs. 3.79%, P=0.0001, respectively), and had lower income (24.32% vs. 17.62%, P=0.0413). By multivariate logistic regression, secondhand smoke increased the prevalence of COPD but was not statistically significant (OR=1.75, P=0.41). Conclusion: There was no significant difference in prevalence of COPD between the never-smokers with and without exposure to secondhand smoke.