Clinical Features of Patients with Solitary Pulmonary Nodule Diagnosed with Chronic Granulomatous Inflammation

분야: 의약학 > 내과학
저자: ( Kyung Hee Kim ) , ( Jin Woo Lee ) , ( Oung Sik Park ) , ( Chang Hoon Lee ) , ( Sang Min Lee ) , ( Jae Joon Yim ) , ( Young Whan Kim ) , ( Sung Koo Han ) , ( Chul Gyu Yoo )
발행기관: 대한결핵 및 호흡기학회
간행물정보: 대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 211(총1페이지)
파일형식: 0y909929.pdf [무료 PDF 뷰어 다운로드]
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영문초록

In some cases of chronic granulomatous inflammation (CGI) patients, if caseous necrosis (CN) is not observed that is characteristically seen in tuberculosis and tuberculosis polymerase chain reaction (PCR) and Interferon-gamma release assay (IGRA) are negative, clinical judgement is often difficult whether tuberculosis treatment should be considered or not in tuberculosis endemic area. We sought to investigate the clinical course of patients shown chronic granulomatous inflammation without caseous necrosis and Ziehl-Neelsen (ZN) staining, tuberculosis polymerase chain reaction (PCR) and interferon-gamma release assay (IGRA) are negative. Medical record were reviewed in 691 patients that histologically proven with chronic granulomatous inflammation from 2001 to 2010 at seoul national university hospital. 575 patients were excluded who were diagnosed with lung cancer, tuberculosis, fungal pneumonia and etc. A total 116 patients were involved in this study. 86 patients were prescribed Tb medication. There was no difference in size changes in both groups at computed tomography during average follow up period of two years. In the group that did not receive Tb medication, Lesions disappeared in 30% of patients, reduced in 46.7% of patients, did not change in 20.0% of patients. Only 3.3% of patients had an increase in the lesion. In conclusion, Tb medication is not necessary in patients shown chronic granulomatous inflammation without caseous necrosis and Ziehl-Neelsen(ZN) staining, tuberculosis polymerase chain reaction (PCR) and interferon-gamma release assay(IGRA) are negative.

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