Subacute Respiratory Infection after Lung Transplantation: 20 yr Experience at Yonsei Medical Center
의약학 > 내과학
김상용 , 신정아 , 변민광 , 김형중 , 안철민 , 함석진 , 이두연 , 백효채 , 장윤수
대한결핵 및 호흡기학회
대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 213(총1페이지)
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    Background: Lung transplantation is one of promising treatment modality for end-stage lung disease. Respiratory infections are a major cause of morbidity and mortality after lung transplantation. The aim of this study is to evaluate respiratory infection of lung transplant (LT) recipients at subacute stage and to render strategy for improving clinical outcome of the patients. Methods: Among the 61 LT recipients, clinical data of 42 lung transplant recipients and donors, who gotten transplanted between 2006 and 2011 were retrospectively analyzed. Subacute respiratory infections were classified according to etiology, occurrence time, and risk factors. Results: The patient mean age was 47.4 years. Interstitial pulmonary fibrosis (IPF) was the disease leading to transplant in 16 recipient (41%) and lymphangioleiomyomatosis (LAM) in 7 (18%.). A total 39 respiratory infections were reported in the 29 out of 42 LT recipients. 33 out of 39 (85%) episodes were reported during the first year after transplantation. Among those 33 episodes, 23 developed within the first 1 months. The most frequent microorganisms were: A. baumannii (n=12; 30.7%), P. aeruginosa (n=6; 15.4%), S. aureus (n=4 10.3%), and CMV (n=4; 10.3%). 2 cases of Mycobaterium were diagnosed, including 1 nontuberculosis mycobacteria (NTM). Conclusion: The critical period for infections after lung transplantation is the first years, especially for those of bacterial etiology. CMV pneumonia have become less frequent, because of prophylaxis with valganciclovir.
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