Alveolar Epithelial Cells Express Markers of Senescence in Lungs from Patients With Idiopathic Pulmonary Fibrosis

분야: 의약학 > 내과학
저자: ( Eun Kyung Kim ) , ( Seung Ick Cha ) , ( Aaron V Schroeder ) , ( Jasleen Kukreja ) , ( Kirk D Jones ) , ( Jeffrey A Golden ) , ( Michael A Matthay ) , ( David J Erle ) , ( Harold R Collard ) , ( Paul J Wolters )
발행기관: 대한결핵 및 호흡기학회
간행물정보: 대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 247(총1페이지)
파일형식: 0y909996.pdf [무료 PDF 뷰어 다운로드]
※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
구매가격: 1,000원
적립금: 30원 (구매자료 3% 적립)

연관 논문

PE-045 : The effect of 12-hydroxyeicosatetraenoic acid in idiopathic pulmonary fibrosis

Original Articles : Inhibition of Plasminogen Activator Inhibitor-1 Expression in Smoke-Exposed Alveolar Type 2 Epithelial Cells Attenuates Epithelial-Mesenchymal Transition

Apolipoprotein A1 Inhibits TGF-β1-Induced Epithelial-to-Mesenchymal Transition of Alveolar Epithelial Cells

P-130 Inhibition of autophagy by Rubicon in idiopathic pulmonary fibrosis

원저 : 각종 간질성폐질환에서 폐포 대식세포의 Superoxide 분비능과 식균 작용 ( Superoxide Production and Phagocytosis by Pulmonary Alveolar Macrophages in Interstitial Lung Disease )

영문초록

Background: The prevalence of idiopathic pulmonary fibrosis (IPF) increases with age. Recent reports have demonstrated that mutations in TERT or TERC and short telomeres are risk factors for the development of IPF. Because short telomeres induce cellular senescence, these findings suggest senescence may occur in IPF lung. Methods: To evaluate for cellular senescence, we compared microRNA (miRNA) expression by miRNA arrays in type II epi-thelial cells. Senescence-associated β-galactosidase staining and immunohistochemical detection of p16, p21 and p53 were examined in sections of lung obtained from IPF patients and normal controls. Results: Expression of miR34-a, -b, and -c, which reportedly induce senescence in human epithelial cells are increased in IPF type II epithelial cells. β-Galactosidase activity is detectable on type II epithelial cells of IPF, but not normal lung. p16, p21 and p53 were detectable by immunostaining in IPF epithelial cells. Conclusions: IPF epithelial cells express several markers of senescence. These results suggest that the senescence of alveolar epithelial cells is accelerated in patients with IPF and may play a role in the pathogenesis of IPF.

추천자료

[PBL] 전신부종과 호흡곤란을 호소한 젊은 여자

폐성심, 곤봉지, 만성 기관지염, 혈액내 가스 분석

[병리학 논문분석] PDL cell과 LPS와 nicotine 처리했을때의 VEGF 발현에 관한 연구

[자연] 구강질환에 대해서

의학용어 약어정리

[의학] 강직성 척추염(ankylosing spondylitis)

[자연] 기침, 혈성객담

[의학] 박테리아 Bacterial disease

[[솔루션]] :: Lehninger Biochemistry 5edition[the foundations of Biochemistry]

[의학] 역류성 식도염(Gastroesophageal Reflux Disease)PBL(영문)

오늘 본 자료