Prolonged Infusion Beta-lactam Therapy in Patients with Ventilator Associated Pneumonia: Pilot Study
분야
의약학 > 내과학
저자
정치량 , 박승용 , 김유지 , 김소리 , 박성주 , 이용철 , 이흥범
발행기관
대한결핵 및 호흡기학회
간행물정보
대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 262(총1페이지)
파일형식
0y910022.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    1,000원
    적립금
    30원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    영문초록
    Although intermittent bolus antibiotic therapy is currently the standard of practice for pneumonia, β-lactams exhibit time-dependent bacterial killing. Use of a prolonged infusion has been advocated for maximizing the time above the MIC compared with intermittent bolus dosing. To examine the clinical properties of the β-lactam antibiotics and the rationale for their prolonged infusion, and to validate reasons that this mode of administration may be replaced intermittent infusion as the standard of practice in ventilator associated pneumonia (VAP). 17 patients, who were diagnosed VAP with gram negative pathogens were examined by chart review observational retrospective study in academic medical intensive care unit in Chonbuk national university hospital. Each received β-lactams by prolonged infusion over 3 hours q8h were assigned. 12 patients have changed to cefepime prolonged infusion, another 5 patient treated with ceftazidime. Negative microbial conversion identified in 4 patients (4/12, 33%). Radiologic improvement disclosed in 10 patients (10/17, 59%). Laboratory findings improved as fol-lows; white blood cell count (12/17, 71%), high sensitive C-reactive protein level (12/17, 71%), procalcitonin level (7/15, 47%). Renal impairment reported in 4 patients (5/17, 29%). Prolonged infusion β-lactam antibiotics may have value in VAP subsets of patients, such as those with highly-resistant Gram-negative infections. The safety profile were acceptable, therefore further enrollment should be scheduled.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.