Background: Prospectively to investigate the efficacy of Pulmonary Rehabilitation (PR) after lung resection in lung cancer patients. Methods: We performed postoperative pulmonary rehabilitation in patients who had lung resection from October 2010 to April 2012. Twenty seven patients accepted the pulmonary rehabilitation and the remaining 7 were taken as controls. We con-ducted pulmonary function test before and 2weeks, 1, 3, 6months after surgery measuring forced expiratory volume in 1 second (FEV1), functional vital capacity (FVC), maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), peak cough flow (PCF) with checking Visual Analog Scale (VAS) for perceived intensity of dyspnea, and Rating of Perceived Dyspnea (RPD) Scale at activities of daily livings (ADLs). Results: All parameters were significantly decreased at 2 weeks after surgery (p＜0.05). From preoperative to 6 months after lung resection, improvement of pulmonary function parameters, and subjective discomfort score were better in pulmonary re-habilitation group, but there was no statistical difference of change of MEP between 2 groups. In patients who received pulmo-nary rehabilitation, FVC was improved between all their measurement interval, but other parameters including FEV1, MIP, MEP, and PCF did not show relative efficacy in the late postoperative phase. Conclusion: PR is not only prevent decline of pulmonary function, but also more helpful to improve the reduced pulmonary function and minimize discomforts of patients undergoing lung resection in postoperative periods.