Introduction: Antibody responses are typically investigated in infectious diseases where antibody production strongly affects patho-genesis and outcome. Determining what constitutes protective immunity to TB is critical for the development of improved diagnostics. The comparison of the immune system between contacts of TB patients, who later develop TB disease (progressors), versus contacts who remain healthy (non-progressors), allows for identification of predictive markers of TB disease. Methodology: A total of 2,567 contacts from the 37 high schools were included. The mean age of the contacts was 15.3 years (range, 14-18), and 1,660 (56.1%) of the contacts were male. The 26 patients who were diagnosed through collection period. Antibody micro-arrays were probed with plasma from 10 patients (61.5%). Whole plasma sample were purified protein derivative from two groups(10 progressors and 10 non-progressors). The 656 of antibodies were measured in supernatants using an Explorer antibody array assay. Result: We found differences in median responses in 18 of the 656 antibodies: 2 higher in TB patients and 5 higher in TB patients and progressors. And 2 proteins are significant different expression who later develop TB disease. Conclusion: Our systems approach to the study of the antibody response in tuberculosis defines the boundaries of the immunologically reactive proteins. But additional experiments are required in order to understand the immune response between TB patients and progressors.