Antituberculosis POTENTIAL of Artemisia Capillaries Single Fractions Against Mycobacterium Tuberculosis
의약학 > 내과학
( Hyun Ji Lee ) , ( Young Hee Kim ) , ( Byung Eui Lee ) , ( Ho Yeon Song )
대한결핵 및 호흡기학회
대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 285(총1페이지)
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    Tuberculosis (TB) is caused by Mycobacterium tuberculosis (MTB). One-third of the world`s populations are infected by MTB but there are very limited kinds of drugs are currently available and most of them were developed in 1950-70`s. Multidrug resistant (MDR) and extensively drug resistant cases are emerging and it is now becoming difficult to treat. Our main goal is to find out some phytochemicals against the highly contagious TB. We have screened 23 fractions of Artemisia capillaris and among them Ursolic acid and hydroquinone were found with great effect against M. tuberculosis H37Ra using resazurin microtitre assay. non-inhibitory concentration (NIC) values were found 4.994 μg/ml and 0.119 μg/ml for Ursolic acid and Hydroquinone respectively. Different concentrations of Ursolic acid and Hydroquinone mixtures were screened against H37Ra using BACTECTM MGIT 960 system to compare the anti-tuberculosis effect with rifampicin and isoniazid. H37Ra cultured with 100μg/ml of Hydroquinone and 100/50/25μg/ml Ursolic acid mixtures showed growth as negative as rifampicin in BACTECTM MGIT 960 system up to 42 days. We investigated TEM images to compare the morphology changes when H37Ra was directly treated with Ursolic acid (100μg/ml), Hydroquinone (100μg/ml) and rifampicin (2μg/ml). Ursolic acid and Hydroquinone were found to develop some morphological changes in the cell wall of H37Ra. Ursolic acid and Hydroquinone might have good potential in the treatment of TB but it need further evaluation.
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