Surgical Treatment for Patients with Symptomatic Synchronous Brain Metastasis from Non-Small Cell Lung Cancer: A Single Center Experience
의약학 > 내과학
김상용 , 신정아 , 장윤수 , 김형중 , 안철민 , 박철환 , 홍창기 , 변민광
대한결핵 및 호흡기학회
대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 288(총1페이지)
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    Background: The optimal treatment for patients with non-small cell lung cancer (NSCLC) with neurologically symptomatic, synchronous brain metastasis still remains controversial. The aim of this study was to analyze our experience with surgical treatment in these patients. Methods: The study was a retrospective review of 25 patients presented with neurologic symptoms, synchronous and multiple or solitary brain metastasis from NSCLC between Apr, 2006 and Dec, 2011. Patients were divided into two groups according to performing neurosurgery for brain metastasis: surgical treatment group (n=12) and non-surgical treatment group (n=13). We compared surgical group with non-surgical group and analyzed overall survival, clinical course, prognostic factors and treatment primary tumor and brain metastasis between two groups. Results: The mean age of the patients was 65.8 years. The histological types included 18 adenocarcinomas, 4 squamous cell carcinoma, 3 NSCLC-not otherwise specified. 11 patients of surgical group received upfront neurosurgical resection for brain metastasis followed by WBRT or stereotactic radiosurgery and 10 patients of non-surgical group received WBRT or stereotactic radiosurgery only. There was no significant difference in overall survival among two groups (surgical group, 11.6 months versus non-surgical group, 10.5 months, respectively; P=0.14). Conclusion: Patients with brain metastases, presenting with neurologic symptoms, showed no survival benefit from combined treatment with neurosurgical resection, although local brain metastasis was improved.
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