A Functional Polymorphism in the Pre-microRNA-146a Is Associated with Risk of Lung Cancer in a Korean Population
의약학 > 내과학
오세림 , ( Hyo Sung Jeon ) , ( Yong Hoon Lee ) , ( Seung Soo Yoo ) , ( Shin Yup Lee ) , ( Jaehee Lee ) , ( Seung Ick Cha ) , ( Chang Ho Kim ) , ( Ji Woong Son ) , ( Jae Yong Park )
대한결핵 및 호흡기학회
대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 291(총1페이지)
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    Introduction: MicroRNAs play important roles in the development and progression of human cancers. It has been reported that miR-146a down-regulates EGFR and the NF-κB regulatory kinase interleukin-1 receptor-associated kinase 1 genes that plays important roles in lung carcinogenesis. This study was conducted to evaluate the association between a functional poly-morphism, rs2910164C>G, in the pre-miR-146a and lung cancer risk. Material and Methods: The rs2910164C>G genotypes were determined in 1,094 lung cancer patients and 1,100 healthy con-trols who were frequency-matched for age and gender. Results: The rs2910164 CG or GG genotype was associated with a significantly decreased risk of lung cancer compared to the CC genotype (adjusted odds ratio [aOR]=0.80, 95% confidence interval [CI]=0.66-0.96, P=0.02). When the cases were cate-gorized by tumor histology, the effect of the rs2910164C>G genotype on the risk of lung cancer was significant in ad-enocarcinoma (aOR=0.74, 95% CI=0.58-0.93, P=0.01) and small cell lung cancer (aOR=0.68, 95% CI=0.46-0.99, P=0.04) but not in squamous cell carcinoma. Conclusions: This finding suggests that the pre-miR-146a rs1910164C>G might be a useful marker for determining the sus-ceptibility to lung cancer and that miR-146a might be involved in the development of lung cancer.
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