Association between Lung Cancer Susceptibility Variants Identified by Genome-Wide Association Studies and Survival of Non-Small Cell Lung Cancer

분야: 의약학 > 내과학
저자: 이소연 , ( Mi Jeong Hong ) , ( Yi Young Choi ) , ( Hyo Sung Jeon ) , ( Seung Soo Yoo ) , ( Shin Yup Lee ) , ( Jaehee Lee ) , ( Seung Ick Cha ) , ( Chang Ho Kim ) , ( Eung Bae Lee ) , ( Jae Yong Park )
발행기관: 대한결핵 및 호흡기학회
간행물정보: 대한결핵및호흡기학회 추계학술발표초록집 2012년, 제114권 292(총1페이지)
파일형식: 0y910081.pdf [무료 PDF 뷰어 다운로드]
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연관 논문

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영문초록

Introduction: A number of genome-wide association studies (GWASs) have identified chromosomal regions containing genes associated with the risk of lung cancer. Genetic polymorphisms influence not only the development of cancer, but also cancer progression and prognosis. Therefore, we investigated the impacts of genetic variants associated with susceptibility to lung cancer in GWASs on the prognosis of NSCLC. Materials and Methods: This study included patients (n=363) with stage I, II, or IIIA (micro-invasive N2) NSCLC who under-went curative surgical resection at the Kyungpook National University Hospital, Daegu, Korea between September 1998 and December 2007. Eight single nucleotide polymorphisms (SNPs) in the six chromosomal regions (CRP rs2808630, FAM13A rs7671167, HHIP rs1489759, GYPA rs2202507, TERT rs2736100, CLPTM1L rs402710, BAT3 rs1052486, and CHRNA5 rs16969968) were genotype by a PCR-RFLP analysis. Results: None of the eight SNPs were significantly associated with overall survival and disease-free survival. In addition, when the patients were categorized according to age, gender, smoking status, tumor histology and pathologic stage, there were no significant associations between the eight SNPs and survival outcomes. Conclusions: These results suggest that the genetic variants identified by GWASs for lung cancer susceptibility are not sig-nificantly associated with the prognosis of patients with early stage NSCLC.

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