Multiple or second primary lung cancers can develop at any sites in the lung with same or different histologic types, synchro-nously and/or metachronously. In case of metachronous occurrence of the second primary lung cancer, it is easy to confuse the primary lung cancer as a recurrence of precedent lung malignancy treated successfully or metastasis. Previous reports have demonstrated that majority of second primary lung malignancies have same histologic types regardless of their developing time and location. However, the repeated occurrence of the second primary lung malignancy, in particular with the different histologic features, is a very rare condition. In this report, we describe a case of subsequent occurrence of second primary lung cancers at different sites in trachea of a 62-year old male who had been treated with left pneumonectomy and adjuvant chemotherapy for squamous cell carcinoma on left main bronchus.