Surgical resection remains as the treatment of choice for non-small cell lung cancer (NSCLC) in early stage. Despite some patients with inadequate respiratory reserve, cardiac dysfunction, vascular disease, or other medical co-morbidities are unable to tolerate the stress during surgery or postoperative period. The need for less invasive alternative therapy has increased. Filling up the need, radiofrequency ablation (RFA) plays a key role in improving and replacing the existing therapies including surgery or chemotherapy. Recent studies have shown that lung RFA is one of the most reliable alternative therapeutic tool for all the stage of lung cancer. Long term follow-up data of pulmonary RFA in terms of safety and efficacy have rarely reported. In fact, there was no report of complete remission (CR) achieved by RFA in advanced lung cancer. We reported a case of achievement of complete remission state for ten years by RFA combined with adjuvant chemotherapy for advanced stage of lung cancer.