Purpose: The purpose of this study was to identify factors influencing quality of life of caregivers using day care services. Methods: Data were collected from 14 different day care services in D city, with a total of 146 female caregivers as participants. All participants were at home caregivers whose patients were senior citizens older than 65. Data were collected from September 1 to 30 of 2008 and analyzed by t-test, ANOVA, Pearson`s correlation coefficient, and stepwise multiple regression. Results: Quality of life among caregivers of day care services differed significantly according to state of health, other caregivers, job, and family income. Quality of life among caregivers showed correlation with caregiving burden. The significant predictors affecting quality of life were state of health, other caregivers, job, and family income and caregiving burden. A combination of these predictors accounted for 43.5% of the variance in quality of life. Conclusion: These findings show that quality of life of family caregivers using day care services is influenced by caregiving burden. Development of day care service programs is necessary in order to reduce caregiving burden of family caregivers for the elderly.