Purpose: This study was performed to provide basic data for nursing intervention plan to improve health related to task by examining whether nurses` burnout is related with job stress, job satisfaction, social support, and self efficacy in hospitals. Methods: The participants were 320 nurses who work at 5 different university hospitals with individual agreement for this study. The questionnaire were provided to the subjects. Data analysis was done by Pearson correlation coefficient and multiple regression were used. Results: Estimated regression model of burnout of nurses was statistically significant (F=119.88, p<.001). Major factors which affect burnout of nurses were job stress (β=.54), job satisfaction (β=-.31), and social support (β=-.20) which explained 53.4% of burnout of nurse. As a result of examining the assumption of the regression, all results were satisfactory with the assumption of the regression equation. Conclusion: Based on the results of the study, It is nacessary to reduce job stress and increse job satisfaction and social support in order to reduce burnout of nurse. Job stress management may be needed mostly because job stress was the highest level of prediction against burnout.